From Albany Airport:
Start out going NORTHWEST on CR-151 / ALBANY SHAKER RD toward NY-155 / CR-153 / WOLF RD. Merge onto I-87 S via the ramp on the LEFT. Take the I-90 E / I-87 S / I-90 W exit- EXIT 1- toward ALBANY / BOSTON / NEW YORK / BUFFALO / NEW YORK THRUWAY. Merge onto NEW YORK STATE TRWY S / I-90 W via EXIT 1W toward NEW YORK / BUFFALO / NEW YORK THRUWAY (Portions toll). Merge onto I-890 W via EXIT 25 toward SCHENECTADY / RT-7 / RT-146 (Portions toll). Take the MICHIGAN AVE exit- EXIT 6. Turn RIGHT onto S BRANDYWINE AVE. Turn RIGHT onto Duane Avenue. End at 450 Duane Avenue.

From Buffalo and Syracuse:
Merge onto I-90 E / NEW YORK STATE TRWY E via EXIT 6 toward ALBANY (Portions toll). Merge onto I-890 E via EXIT 26 toward SCHENECTADY. Take EXIT 6 toward CALIFORNIA AVE. Turn LEFT onto MICHIGAN AVE. Merge onto S BRANDYWINE AVE. Turn RIGHT onto Duane Avenue. End at 450 Duane Avenue.

From Boston:
Merge onto I-90 W (Portions toll). Merge onto NEW YORK STATE TRWY W (Portions toll). Merge onto NEW YORK STATE TRWY N / I-87 N toward I-90 / ALBANY / BUFFALO (Portions toll). NEW YORK STATE TRWY N / I-87 N becomes NEW YORK STATE TRWY W / I-90 W (Portions toll). Merge onto I-890 W via EXIT 25 toward SCHENECTADY / RT-7 / RT-146 (Portions toll). Take the MICHIGAN AVE exit- EXIT 6. Turn RIGHT onto S BRANDYWINE AVE. Turn RIGHT onto Duane Avenue. End at 450 Duane Avenue.

From Montreal & Plattsburgh:
Merge onto I-87 S via the ramp on the LEFT. Take the I-90 E / I-87 S / I-90 W exit- EXIT 1- toward ALBANY / BOSTON / NEW YORK / BUFFALO / NEW YORK THRUWAY. Merge onto NEW YORK STATE TRWY S / I-90 W via EXIT 1W toward NEW YORK / BUFFALO / NEW YORK THRUWAY (Portions toll). Merge onto I-890 W via EXIT 25 toward SCHENECTADY / RT-7 / RT-146 (Portions toll). Take the MICHIGAN AVE exit- EXIT 6. Turn RIGHT onto S BRANDYWINE AVE. Turn RIGHT onto Duane Avenue. End at 450 Duane Avenue.

From NYC:
Take the NYS Thruway north to I-87. Take the I-90 E / I-87 S / I-90 W exit- EXIT 1- toward ALBANY / BOSTON / NEW YORK / BUFFALO / NEW YORK THRUWAY. Merge onto NEW YORK STATE TRWY S / I-90 W via EXIT 1W toward NEW YORK / BUFFALO / NEW YORK THRUWAY (Portions toll). Merge onto I-890 W via EXIT 25 toward SCHENECTADY / RT-7 / RT-146 (Portions toll). Take the MICHIGAN AVE exit- EXIT 6. Turn RIGHT onto S BRANDYWINE AVE. Turn RIGHT onto Duane Avenue. End at 450 Duane Avenue.

From Binghamton:
Take I-88 North to I-90 East. Merge onto I-890 E via EXIT 26 toward SCHENECTADY. Take EXIT 6 toward CALIFORNIA AVE. Turn LEFT onto MICHIGAN AVE. Merge onto S BRANDYWINE AVE. Turn RIGHT onto Duane Avenue. End at 450 Duane Avenue.